Psilocybin: Multiple Phase II and III trials show that one or two doses of psilocybin, combined with preparatory and integrative psychotherapy, can produce rapid and significant reductions in depressive symptoms, with effects lasting for months. dutsi rilbu psychedelic.
Ketamine: Already approved as a nasal spray (esketamine, Spravato®) for TRD. It works on a different mechanism (glutamate system) and provides rapid relief (within hours), often used as a bridge while other treatments take effect.
MDMA-Assisted Therapy: This is the most advanced area. Phase III trials have been exceptionally promising, showing that MDMA significantly enhances the psychotherapy process. It reduces fear and defensiveness while increasing trust and empathy, allowing patients to process traumatic memories without being overwhelmed. The FDA has designated it a “Breakthrough Therapy” and it is on track for potential approval (possibly 2024-2025).
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