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Moreover, research indicates that psilocybin’s impact on the default mode network (DMN) is particularly noteworthy. The DMN plays a crucial role in self-referential thought and perception of time and space. Order Online Here. A study revealed that while the initial effects of psilocybin typically reverse within 24 hours, disruptions in communication between the DMN and hippocampus persist for up to three weeks post-ingestion (Davis, 2024). These prolonged effects could underlie potential therapeutic benefits for conditions such as depression.